Huihui Zeng Selected Research

Thioredoxin-Disulfide Reductase

1/2021	Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway.
1/2019	The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen.
1/2019	Thioredoxin Reductase as a Novel and Efficient Plasma Biomarker for the Detection of Non-Small Cell Lung Cancer: a Large-scale, Multicenter study.
9/2017	Synergism between thioredoxin reductase inhibitor ethaselen and sodium selenite in inhibiting proliferation and inducing death of human non-small cell lung cancer cells.
6/2012	Inhibition of thioredoxin reductase by a novel series of bis-1,2-benzisoselenazol-3(2H)-ones: Organoselenium compounds for cancer therapy.
1/2011	Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity.
10/2008	The inhibitory effect of a novel organoselenium compound BBSKE on the tongue cancer Tca8113 in vitro and in vivo.
1/2007	The mechanism of apoptosis induced by a novel thioredoxin reductase inhibitor in A549 cells: possible involvement of nuclear factor-kappaB-dependent pathway.
5/2006	A thioredoxin reductase inhibitor induces growth inhibition and apoptosis in five cultured human carcinoma cell lines.

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Huihui Zeng Research Topics

Disease

16	Neoplasms (Cancer) 01/2022 - 09/2003
8	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 06/2012
6	Emphysema 01/2021 - 01/2013
4	Breast Neoplasms (Breast Cancer) 11/2020 - 05/2010
3	Infections 01/2022 - 04/2015
3	Pneumonia (Pneumonitis) 01/2021 - 01/2020
3	Inflammation (Inflammations) 01/2021 - 01/2015
3	COVID-19 01/2021 - 01/2020
3	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2020 - 09/2017
2	Neoplasm Metastasis (Metastasis) 06/2020 - 06/2012
2	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 09/2013
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/2022
1	Asthma (Bronchial Asthma) 01/2021
1	Hypertension (High Blood Pressure) 01/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021
1	Stomach Neoplasms (Stomach Cancer) 01/2021
1	Non-alcoholic Fatty Liver Disease 01/2021
1	Leukemia 09/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 09/2020
1	Coinfection 01/2020
1	Healthcare-Associated Pneumonia 01/2020
1	Critical Illness (Critically Ill) 01/2020
1	Birth Weight (Birth Weights) 01/2019
1	Liver Neoplasms (Liver Cancer) 01/2018
1	Necrosis 09/2017
1	Pulmonary Emphysema 01/2017
1	Colorectal Neoplasms (Colorectal Cancer) 10/2016
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 10/2016
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2016
1	Lymphoma (Lymphomas) 01/2016
1	Chronic Hepatitis B 04/2015
1	Tics (Tic) 01/2015
1	Adenocarcinoma of Lung 09/2013

Drug/Important Bio-Agent (IBA)

9	Thioredoxin-Disulfide ReductaseIBA 01/2021 - 05/2006
8	SmokeIBA 01/2021 - 01/2013
8	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2003
5	(1,2- bis(1,2- benzisoselenazolone- 3(2H)- ketone))ethaneIBA 01/2019 - 01/2011
4	Pharmaceutical PreparationsIBA 01/2021 - 03/2012
4	EthaneIBA 01/2011 - 09/2003
4	KetonesIBA 01/2011 - 09/2003
3	AntioxidantsIBA 01/2021 - 01/2017
2	butaselenIBA 05/2022 - 01/2021
2	ThioredoxinsIBA 01/2021 - 09/2003
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 01/2020
2	Biomarkers (Surrogate Marker)IBA 11/2020 - 01/2019
1	ebselenIBA 05/2022
1	SteroidsIBA 01/2022
1	GoldIBA 01/2022
1	CollagenIBA 01/2021
1	Competitive Endogenous RNAIBA 01/2021
1	Histones (Histone)IBA 01/2021
1	ProcalcitoninIBA 01/2021
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2021
1	Protein MethyltransferasesIBA 01/2021
1	SeleniumIBA 01/2021
1	SilymarinIBA 01/2021
1	Formoterol Fumarate (Oxis)FDA Link 01/2021
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021
1	Budesonide (Pulmicort)FDA LinkGeneric 01/2021
1	fibrin fragment D (D-dimer)IBA 01/2021
1	F-Box ProteinsIBA 01/2021
1	Therapeutic UsesIBA 01/2021
1	Long Noncoding RNAIBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2020
1	Starch (Cornstarch)IBA 06/2020
1	Biological ProductsIBA 06/2020
1	Fatty Acids (Saturated Fatty Acids)IBA 06/2020
1	Alanine (L-Alanine)FDA Link 06/2020
1	Circular RNAIBA 06/2020
1	Tyrosine (L-Tyrosine)FDA Link 06/2020
1	RNA (Ribonucleic Acid)IBA 06/2020
1	Anaplastic Lymphoma KinaseIBA 01/2020
1	Polymyxin B (Aerosporin)FDA LinkGeneric 01/2020
1	NF-kappa B (NF-kB)IBA 01/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2019
1	Selenious Acid (Selenite)IBA 09/2017
1	Sodium SeleniteIBA 09/2017
1	Peptide Hydrolases (Proteases)FDA Link 01/2017
1	Imatinib Mesylate (Gleevec)FDA Link 10/2016
1	Sunitinib (Sutent)FDA Link 10/2016
1	Tyrosine Kinase InhibitorsIBA 10/2016
1	Telbivudine FDA Link 04/2015
1	Dihydrotachysterol (AT 10)IBA 01/2015
1	SuspensionsIBA 01/2015
1	Serum-Free Culture MediaIBA 01/2015
1	Sirtuin 3IBA 09/2013
1	Organoselenium CompoundsIBA 06/2012

Therapy/Procedure

4	Therapeutics 01/2022 - 06/2012
2	Transplantation 01/2022 - 01/2017
1	Drug Therapy (Chemotherapy) 01/2022
1	Radiotherapy 01/2022
1	Ambulatory Care (Outpatient Care) 01/2021
1	Oral Administration 01/2021
1	Intraperitoneal Injections 01/2021
1	Continuous Renal Replacement Therapy 01/2021
1	Artificial Respiration (Mechanical Ventilation) 01/2021
1	Extracorporeal Membrane Oxygenation 01/2021
1	Cardiopulmonary Resuscitation (CPR) 01/2020
1	Chemoprevention 01/2018
1	Homologous Transplantation 01/2017